Protein Labeling Reagents
eMolecules 25535-16-4 | Medchem Express | Propidium (Iodide) | 10mg | 446274299 | HY-D0815 | MFCD00011921 | 668.406 | C27H34I2N4
Medchem Express | W-7 (hydrochloride) | 25mg | 536983735 | HY-100912 | 61714-27-0 | MFCD00012559 | 377.320 | C16H22Cl2N2O2S
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Broadpharm BDP FL NHS ester | 146616-66-2 | MFCD00467385 | 25 mg
BDP FL NHS ester | Purity: 96% | Mol Wt: 389.2 | 146616-66-2 | MFCD00467385 | 25 mg
Biotium CD26(202-36), CF488A conjugate, 0.1mg/mL
Recognizes a glycoprotein of 110 kDa, identified as CD26 (Workshop VI; Code: N-L039). It is an atypical serine protease belonging to the prolyl oligopeptidase family. It is expressed on lymphocyte cells and is upregulated during T-cell activation. CD26 is also expressed on activated B cells and natural killer cells and abundantly on epithelia. CD26 is implicated in a variety of biological functions including T-cell activation, cell adhesion with extracellular matrix such as fibronectin or collagens, and in HIV infection. Cross-linking of CD26 using this antibody dramatically enhances the anti-CD3-induced IL-2 production. In Western blotting, this MAb reacts with only glycosylated CD26, but not with the deglycosylated form. It does not prevent ADA binding to CD26.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405
Biotium c-Myc(MYC275), CF488A conjugate, 0.1mg/mL
The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies also have shown that c-Myc is essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells, and which brought extensive attention in the development of new therapeutic approach for cancer treatment.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability.
Biotium CD45 / LCA(2B11 + PD7/26), CF488A conjugate, 0.1mg/mL
CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. This MAb reacts with all isoforms of CD45R expressed by all hematopoietic cells, except erythrocytes, having a higher level of expression on lymphocytes than on granulocytes (Workshop IV). Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplas
(F)F.CN1\C(=C\C=C\C2=[N+](CCCCCC(=O)NCc3ccc(cc3)-c3nnc(C)nn3)c3ccccc3C2(C)C)C(C)(C)c2ccccc12 | 5mg | 374905208](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502513205.JPG-250.jpg)
eMolecules 2183473-57-4 | Cy3 methyltetrazine | Broadpharm727.660 | C40H46BF4N7O | 98.000 | F[B-](F)(F)F.CN1\C(=C\C=C\C2=[N+](CCCCCC(=O)NCc3ccc(cc3)-c3nnc(C)nn3)c3ccccc3C2(C)C)C(C)(C)c2ccccc12 | 5mg | 374905208
Cy3 methyltetrazine | Broadpharm | 2183473-57-4727.660 | C40H46BF4N7O | 98.000 | F[B-](F)(F)F.CN1\C(=C\C=C\C2=[N+](CCCCCC(=O)NCc3ccc(cc3)-c3nnc(C)nn3)c3ccccc3C2(C)C)C(C)(C)c2ccccc12 | 5mg | 374905208
Biotium Fascin-1(FSCN1/418), CF488A conjugate, 0.1mg/mL
Recognizes a protein of 55 kDa, which is identified as fascin-1. Its actin binding ability is regulated by phosphorylation. Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkin's disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Fascin-1 is also expressed in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection o
Biotium CD43(DF-T1), CF568 conjugate, 0.1mg/mL
This antibody recognizes a cell surface glycoprotein of 95/115/135 kDa (depending upon the extent of glycosylation), identified as CD43 . Epitope of MAb Bra7G is clearly different from that of MAb DF-T1, called b as opposed to a for DF-T1. 70-90% of T-cell lymphomas and from 22-37% of B-cell lymphomas express CD43. No reactivity has been observed with reactive B-cells. So a B-lineage population that co-expresses CD43 is highly likely to be a malignant lymphoma, especially a low-grade lymphoma, rather than a reactive B-cell population. When CD43 antibody is used in combination with anti-CD20, effective immunophenotyping of the lymphomas in formalin-fixed tissues can be obtained. Co-staining of a lymphoid infiltrate with anti-CD20 and anti-CD43 argues against a reactive process and favors a diagnosis of lymphoma.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note